The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
BUTALACTIN, A NEW BUTANOLIDE ANTIBIOTIC
TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITY
CHRISTOPHER M. M. FRANCOURMILA P. BORDEE. K. S. VIJAYAKUMARSUGATA CHATTERJEEJURGEN BLUMBACHBIMAL N. GANGULI
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1991 Volume 44 Issue 2 Pages 225-231

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Abstract

Butalactin, [2-(4', 5'-epoxy-hex-2'(E)-en)oyl-2-hydroxy-3-hydroxymethyl-2, 3-(Z)-butanolide] is a new antibiotic produced by Streptomyces sp. HIL Y-86, 36923. Taxonomically, the producing organism most closely resembles Streptomyces corchorusii. The strain also produces cineromycin B. Though butalactin is structurally related to 'signal molecules' such as A-factor, the anthracycline inducing factors and the virginiae butanolides, it does not show inducing activity for antibiotic production or aerial mycelium formation in the indicator strain. Butalactin possesses a weak antibiotic activity against Gram-positive and Gram-negative bacteria.

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