A NEW ANTIBIOTIC, OKICENONE I. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL CHARACTERISTICS

KANKI KOMIYAMA; SHINJI FUNAYAMA; YUMI ANRAKU; MASAMI ISHIBASHI; YOKO TAKAHASHI; TAKATOSHI KAWAKAMI; SATOSHI OMURA

doi:10.7164/antibiotics.44.814

A NEW ANTIBIOTIC, OKICENONE

I. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL CHARACTERISTICS

KANKI KOMIYAMA, SHINJI FUNAYAMA, YUMI ANRAKU, MASAMI ISHIBASHI, YOKO TAKAHASHI, TAKATOSHI KAWAKAMI, SATOSHI OMURA

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JOURNAL FREE ACCESS

1991 Volume 44 Issue 8 Pages 814-818

DOI https://doi.org/10.7164/antibiotics.44.814

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Abstract

A new antibiotic, okicenone was isolated from the culture broth of Streptomyces sp. KO-3599. The antibiotic possesses cytocidal activity against mammalian tumor cells in vitro at concentrations of 0.53-11.0μg/ml whereas the antibiotic showed no antimicrobial activities against Gram-positive and Gram-negative bacteria, fungi or yeast at a concentration of 1, 000μg/ml.

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