The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
CONVERSION OF BIALAPHOS TO OTHER OLIGOPEPTIDES CONTAINING PHOSPHINOTHRICIN BY Streptomyces hygroscopicus
YOICHI KUMADASATOSHI IMAIKOZO NAGAOKA
Author information
JOURNAL FREE ACCESS

1991 Volume 44 Issue 9 Pages 1006-1012

Details
Abstract

Two oligopeptides containing phosphinothricin were accumulated in the culture of bialaphos (BA) producer Streptomyces hygroscopicus SF1293 when large amount of BA was added to the culture at idio phase. One of the oligopeptides was a new substance, BA dimer (phosphinothricyl-alanyl-alanyl-phosphinothricyl-alanyl-alanine), and the other was a known substance called If (phosphinothricyl-alanyl-alanyl-phosphinothricin). Though BA none producing mutants which were blocked at the steps 1, 10 and 13, respectively in BA biosynthesis also converted BA to BA dimer and If, the mutants blocked at the step 11 (alanylation) could not curry out the conversion. Antibiotic activities of BA dimer and If were lower than 1/100 of BA.

Content from these authors
© Japan Antibiotics Research Association
Previous article Next article
feedback
Top