NEW N-ALKYL DERIVATIVES OF AMPHOTERICIN B SYNTHESIS AND BIOLOGICAL PROPERTIES

ANDRZEJ CZERWINSKI; WILFRIED A. KÖNIG; TERESA ZIENIAWA; PAWEL SOWINSKI; VOLKER SINNWELL; SLAWOMIR MILEWSKI; EDWARD BOROWSKI

doi:10.7164/antibiotics.44.979

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

NEW N-ALKYL DERIVATIVES OF AMPHOTERICIN B SYNTHESIS AND BIOLOGICAL PROPERTIES

ANDRZEJ CZERWINSKI, WILFRIED A. KÖNIG, TERESA ZIENIAWA, PAWEL SOWINSKI, VOLKER SINNWELL, SLAWOMIR MILEWSKI, EDWARD BOROWSKI

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1991 Volume 44 Issue 9 Pages 979-984

DOI https://doi.org/10.7164/antibiotics.44.979

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Abstract

The synthesis of new N-alkyl amphotericin B derivatives obtained in the Michael addition reaction of the antibiotic with N-substituted maleimides is described and in vitro biological data are presented.

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