PROTACTIN, A NEW ANTIBIOTIC METABOLITE AND A POSSIBLE PRECURSOR OF THE ACTINOMYCINS

MINORU HANADA; KOKO SUGAWARA; YUJI NISHIYAMA; HIDEO KAMEI; MASAMI HATORI; MASATAKA KONISHI

doi:10.7164/antibiotics.45.20

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

PROTACTIN, A NEW ANTIBIOTIC METABOLITE AND A POSSIBLE PRECURSOR OF THE ACTINOMYCINS

MINORU HANADA, KOKO SUGAWARA, YUJI NISHIYAMA, HIDEO KAMEI, MASAMI HATORI, MASATAKA KONISHI

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JOURNAL FREE ACCESS

1992 Volume 45 Issue 1 Pages 20-28

DOI https://doi.org/10.7164/antibiotics.45.20

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Abstract

Streptomyces cucumerosporus strain L703-4 (ATCC 53784) produces a new 4-methyl-3-hydroxyanthraniloylpentapeptide lactone for which we have proposed the name protactin, in addition to several actinomycin components. Protactin is rather resistant to air oxidation but it can be converted to a new actinomycin, actinomycin Zp by ferricyanide oxidation. Actinomycin Zp possesses in vitro antibacterial activity and in vivo antitumor activity against P-388 leukemia in mice.

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