The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
WS-7338, NEW ENDOTHELIN RECEPTOR ANTAGONISTS ISOLATED FROM Streptomyces sp. No. 7338
I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES
SUSUMU MIYATAMICHIZANE HASHIMOTOYUKO MASUIMASAMI EZAKISHIGEHIRO TAKASEMOTOAKI NISHIKAWASUMIO KIYOTOMASAKUNI OKUHARAMASANOBU KOHSAKA
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1992 Volume 45 Issue 1 Pages 74-82

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Abstract

WS-7338 A, B, C and D, novel endothelin receptor antagonists, have been isolated from fermentation broth of Streptomyces sp. No. 7338. These antagonists were purified from the culture mycelium by extraction with acetone, followed by carbon column chromatography and HPLC. Among them, WS-7338 B showed good activity in an endothelin receptor binding assay with an IC50 of2.7×10-7M.

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