The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
THE IN VITRO PROFILE OF SELECTED 14-MEMBERED AZALIDES
A. BRIAN JONESCHARMAINE M. HERBERT
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1992 Volume 45 Issue 11 Pages 1785-1791

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Abstract

The in vitro antimicrobial potency of 10-aza-9-deoxo-11-deoxyerythromycin A, the first member of a new class of macrolide antibiotic, was determined. Several other members of this family of azalide were prepared and similarly screened in order to begin to define the antibiotic potential of the class. The results indicate that the SAR for this structural type parallels that of other macrolides and that it offers no apparent benefit over known 15-membered azalides.

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© Japan Antibiotics Research Association
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