DACTYLOCYCLINES, NOVEL TETRACYCLINE DERIVATIVES PRODUCED BY A Dactylosporangium sp. III. ABSOLUTE STEREOCHEMISTRY OF THE DACTYLOCYCLINES

PRATIK V. DEVASTHALE; LESTER A. MITSCHER; HANUMAIAH TELIKEPALLI; DAVID VANDER VELDE; JING-YUAN ZOU; HELEN A. AX; ADRIENNE A. TYMIAK

doi:10.7164/antibiotics.45.1907

DACTYLOCYCLINES, NOVEL TETRACYCLINE DERIVATIVES PRODUCED BY A Dactylosporangium sp.

III. ABSOLUTE STEREOCHEMISTRY OF THE DACTYLOCYCLINES

PRATIK V. DEVASTHALE, LESTER A. MITSCHER, HANUMAIAH TELIKEPALLI, DAVID VANDER VELDE, JING-YUAN ZOU, HELEN A. AX, ADRIENNE A. TYMIAK

Author information

JOURNAL FREE ACCESS

1992 Volume 45 Issue 12 Pages 1907-1913

DOI https://doi.org/10.7164/antibiotics.45.1907

Details

Abstract

The dactylocycline antibiotics were found through circular dichroism measurements, NMR spectroscopy and chemical transformations to possess the usual tetracycline family absolute configuration at carbons 4, 4a, 5a and 12a. The absolute stereochemistry about the C-6 carbon, however, was the reverse of that found with previously investigated tetracyclines.

Corresponding author

Register with J-STAGE for free!