A NEW SERIES OF NATURAL ANTIFUNGALS THAT INHIBIT P450 LANOSTEROL C-14 DEMETHYLASE I. TAXONOMY, FERMENTATION, ISOLATION AND STRUCTURAL ELUCIDATION

SHOKO MATSUKUMA; TATSUO OHTSUKA; HIROMICHI KOTAKI; HARUYOSHI SHIRAI; TAKASHI SANO; KIMIHIRO WATANABE; NOBORU NAKAYAMA; YOSHIKO ITEZONO; MORIO FUJIU; NOBUO SHIMMA; KAZUTERU YOKOSE; TORU OKUDA

doi:10.7164/antibiotics.45.151

A NEW SERIES OF NATURAL ANTIFUNGALS THAT INHIBIT P450 LANOSTEROL C-14 DEMETHYLASE

I. TAXONOMY, FERMENTATION, ISOLATION AND STRUCTURAL ELUCIDATION

SHOKO MATSUKUMA, TATSUO OHTSUKA, HIROMICHI KOTAKI, HARUYOSHI SHIRAI, TAKASHI SANO, KIMIHIRO WATANABE, NOBORU NAKAYAMA, YOSHIKO ITEZONO, MORIO FUJIU, NOBUO SHIMMA, KAZUTERU YOKOSE, TORU OKUDA

Author information

SHOKO MATSUKUMA
Nippon Roche Research Center
TATSUO OHTSUKA
Nippon Roche Research Center
HIROMICHI KOTAKI
Nippon Roche Research Center
HARUYOSHI SHIRAI
Nippon Roche Research Center
TAKASHI SANO
Nippon Roche Research Center
KIMIHIRO WATANABE
Nippon Roche Research Center
NOBORU NAKAYAMA
Nippon Roche Research Center
YOSHIKO ITEZONO
Nippon Roche Research Center
MORIO FUJIU
Nippon Roche Research Center
NOBUO SHIMMA
Nippon Roche Research Center
KAZUTERU YOKOSE
Nippon Roche Research Center
TORU OKUDA
Nippon Roche Research Center

JOURNAL FREE ACCESS

1992 Volume 45 Issue 2 Pages 151-159

DOI https://doi.org/10.7164/antibiotics.45.151

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Abstract

A new series of antifungal antibiotics, Ro 09-1470 and its 6 congeners were isolated from the fermentation broth of Penicillium sp. NR6564. Their structures were determined as tetrahydropyran derivatives with an alkenyl side chain on the basis of their spectroscopic and physico-chemical properties. Among these compounds, Ro 09-1470 and Ro 09-1545 possessing a glycyl or an N-substituted glycyl ester residue had high antifungal activity. Ro 09-1469, one of the congeners, was found in the fermentation broth of several strains of Aspergillus sclerotiorum Huber.

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