A NEW ANTITUMOR ANTIBIOTIC PRODUCT, DEMETHYLCHARTREUSIN ISOLATION AND BIOLOGICAL ACTIVITIES

YOSHIYUKI AOYAMA; TAIJI KATAYAMA; MASASHI YAMAMOTO; HISAKI TANAKA; KENJI KON

doi:10.7164/antibiotics.45.875

A NEW ANTITUMOR ANTIBIOTIC PRODUCT, DEMETHYLCHARTREUSIN

ISOLATION AND BIOLOGICAL ACTIVITIES

YOSHIYUKI AOYAMA, TAIJI KATAYAMA, MASASHI YAMAMOTO, HISAKI TANAKA, KENJI KON

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JOURNAL FREE ACCESS

1992 Volume 45 Issue 6 Pages 875-878

DOI https://doi.org/10.7164/antibiotics.45.875

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Abstract

A new antitumor antibiotic, 3''-demethylchartreusin was isolated from the culture broth of Streptomyces chartreusis, as a minor component of crude chartreusin. It is structurally related to chartreusin, containing same aglycone of chartreusin, but different sugar moieties. 3''-Demethylchartreusin exhibits some potent inhibitory activities against murine tumors.

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