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The Journal of Antibiotics
Vol. 45 (1992) No. 6 P 886-891

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http://doi.org/10.7164/antibiotics.45.886


As a result of screening for inhibitors of glycerol-3-phosphate dehydrogenase, which may be effective to prevent corpulence, we isolated two inhibitors named adipostatin A and adipostatin B from the culture broth of Streptomyces cyaneus 2299-SV1. Their structures have been established to be 5-n-pentadecylresorcinol and 5-isopentadecylresorcinol, respectively. Adipostatin A and adipostatin B inhibited glycerol-3-phosphate dehydrogenase at the IC50 values of 4.1 μM and 4.5μM, respectively. These compounds prevented triglyceride accumulation in 3T3-L1 cells at a concentration of the μM level.

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