The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
ADIPOSTATINS A AND B, NEW INHIBITORS OF GLYCEROL-3-PHOSPHATE DEHYDROGENASE
NOBUAKI TSUGEMAKIKO MIZOKAMISHINSUKE IMAIAKIRA SHIMAZUHARUO SETO
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1992 Volume 45 Issue 6 Pages 886-891

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Abstract

As a result of screening for inhibitors of glycerol-3-phosphate dehydrogenase, which may be effective to prevent corpulence, we isolated two inhibitors named adipostatin A and adipostatin B from the culture broth of Streptomyces cyaneus 2299-SV1. Their structures have been established to be 5-n-pentadecylresorcinol and 5-isopentadecylresorcinol, respectively. Adipostatin A and adipostatin B inhibited glycerol-3-phosphate dehydrogenase at the IC50 values of 4.1 μM and 4.5μM, respectively. These compounds prevented triglyceride accumulation in 3T3-L1 cells at a concentration of the μM level.

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© Japan Antibiotics Research Association
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