1992 Volume 45 Issue 6 Pages 892-898
Two new platelet aggregation inhibitors, PI-200 and PI-201 were isolated from the fermentation broth of Streptomyces sp. A7498. PI-200 and PI-201 inhibited ADP-induced aggregation of rabbit platelets with an IC50 of 3.8 × 10-4M and 7.1 × 10-4M, respectively.