The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
PI-200 AND PI-201, NEW PLATELET AGGREGATION INHIBITORS PRODUCED BY Streptomyces sp. A7498
TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES, STRUCTURE DETERMINATION AND BIOLOGICAL PROPERTIES
YUKO KISHIMURAAKIRA KAWASHIMATERUMI KAGAMIZONOMICHIO YAMAGISHIKEITA MATSUMOTOYUTAKA KAWASHIMAKAZUNORI HANADA
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1992 Volume 45 Issue 6 Pages 892-898

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Abstract

Two new platelet aggregation inhibitors, PI-200 and PI-201 were isolated from the fermentation broth of Streptomyces sp. A7498. PI-200 and PI-201 inhibited ADP-induced aggregation of rabbit platelets with an IC50 of 3.8 × 10-4M and 7.1 × 10-4M, respectively.

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© Japan Antibiotics Research Association
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