PI-200 AND PI-201, NEW PLATELET AGGREGATION INHIBITORS PRODUCED BY Streptomyces sp. A7498 TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES, STRUCTURE DETERMINATION AND BIOLOGICAL PROPERTIES

YUKO KISHIMURA; AKIRA KAWASHIMA; TERUMI KAGAMIZONO; MICHIO YAMAGISHI; KEITA MATSUMOTO; YUTAKA KAWASHIMA; KAZUNORI HANADA

doi:10.7164/antibiotics.45.892

PI-200 AND PI-201, NEW PLATELET AGGREGATION INHIBITORS PRODUCED BY Streptomyces sp. A7498

TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES, STRUCTURE DETERMINATION AND BIOLOGICAL PROPERTIES

YUKO KISHIMURA, AKIRA KAWASHIMA, TERUMI KAGAMIZONO, MICHIO YAMAGISHI, KEITA MATSUMOTO, YUTAKA KAWASHIMA, KAZUNORI HANADA

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JOURNAL FREE ACCESS

1992 Volume 45 Issue 6 Pages 892-898

DOI https://doi.org/10.7164/antibiotics.45.892

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Abstract

Two new platelet aggregation inhibitors, PI-200 and PI-201 were isolated from the fermentation broth of Streptomyces sp. A7498. PI-200 and PI-201 inhibited ADP-induced aggregation of rabbit platelets with an IC₅₀ of 3.8 × 10^-4M and 7.1 × 10^-4M, respectively.

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