The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
LEUALACIN, A NOVEL CALCIUM BLOCKER FROM Hapsidospora irregularis
I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES
KIYOSHI HAMANOMASAKO KINOSHITAKOUHEI FURUYAMASAAKI MIYAMOTOYASUYUKI TAKAMATSUATSUKO HEMMIKAZUHIKO TANZAWA
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1992 Volume 45 Issue 6 Pages 899-905

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Abstract

A new calcium blocker, designated leualacin, has been isolated from Hapsidospora irregularis. The compound inhibits the binding of 3H-nitrendipine, a well known synthetic calcium blocker, to cardiac Ca channel in a competitive manner, although its structure is completely different from dihydropyridines.

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© Japan Antibiotics Research Association
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