J-STAGE Home  >  Publications - Top  > Bibliographic Information

The Journal of Antibiotics
Vol. 45 (1992) No. 6 P 914-921

Language:

http://doi.org/10.7164/antibiotics.45.914


Screening of microbial fermentation broths for herbicidal activity led to the discovery of a novel polyketide, herboxidiene, from an actinomycete identified as a member of the Streptomyces chromofuscus cluster. A 14- to 20-fold increase in fermentation production of herboxidiene was achieved as a result of media optimization. Herboxidiene was purified using successive reverse phase C18 steps and Sephadex LH-20 chromatography. Its molecular formula, C25H42O6, was determined by HRFAB-MS. Herboxidiene demonstrated exceptionally potent, selective, herbicidal activity against a variety of weed species and was inactive against wheat, even at rates as high as 5.6 kg/hectare.

Copyright © Japan Antibiotics Research Association

Article Tools

Share this Article