ISOLATION AND STRUCTURE ELUCIDATION OF NEW ANTIBIOTICS RELATED TO ANGOLAMYCIN

Abstract

Angolamycin (1) and two novel analogues (2 and 3) were isolated from the culture broth of a Streptomyces strain. NMR and MS analysis proved that 2 is the 18-dihydro-, while 3 is the 18-deoxo-18-dihydro derivative of angolamycin. Full experimental assignment of the ¹H and the ¹³C NMR spectra of these compounds was obtained from ID and 2D chemical shift correlation measurements. Compounds 2 and 3 are less potent antibiotics than angolamycin.