SULTRIECIN A NEW ANTIFUNGAL AND ANTITUMOR ANTIBIOTIC FROM Streptomyces roseiscleroticus PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITY

HIROAKI OHKUMA; NOBUAKI NARUSE; YUJI NISHIYAMA; TAKASHI TSUNO; YUTAKA HOSHINO; YOSUKE SAWADA; MASATAKA KONISHI; TOSHIKAZU OKI

doi:10.7164/antibiotics.45.1239

SULTRIECIN A NEW ANTIFUNGAL AND ANTITUMOR ANTIBIOTIC FROM Streptomyces roseiscleroticus

PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITY

HIROAKI OHKUMA, NOBUAKI NARUSE, YUJI NISHIYAMA, TAKASHI TSUNO, YUTAKA HOSHINO, YOSUKE SAWADA, MASATAKA KONISHI, TOSHIKAZU OKI

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JOURNAL FREE ACCESS

1992 Volume 45 Issue 8 Pages 1239-1249

DOI https://doi.org/10.7164/antibiotics.45.1239

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Abstract

Streptomyces roseiscleroticus L827-7 (ATCC 53903) produced a novel antifungal and antitumor antibiotic, sultriecin. It exhibited in vitro antifungal activity and potent in vivo antitumor activity against P388 and L1210 leukemias, and B16 melanoma. Sultriecin is composed of several unique structural units; a conjugated triene, an α, β-unsaturated (5-lactone, and a sulfate functionality.

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