NEW ANTIVIRAL ANTIBIOTICS, CYCLOVIRACINS B1 AND B2 I. PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITY

MLTSUAKI TSUNAKAWA; NOBUJIRO KOMIYAMA; OSAMU TENMYO; KOJI TOMITA; KIMIO KAWANO; CHIKAKO KOTAKE; MASATAKA KONISHI; TOSHIKAZU OKI

doi:10.7164/antibiotics.45.1467

NEW ANTIVIRAL ANTIBIOTICS, CYCLOVIRACINS B₁ AND B₂

I. PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITY

MLTSUAKI TSUNAKAWA, NOBUJIRO KOMIYAMA, OSAMU TENMYO, KOJI TOMITA, KIMIO KAWANO, CHIKAKO KOTAKE, MASATAKA KONISHI, TOSHIKAZU OKI

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JOURNAL FREE ACCESS

1992 Volume 45 Issue 9 Pages 1467-1471

DOI https://doi.org/10.7164/antibiotics.45.1467

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Abstract

Kibdelosporangium albatum No. R761-7 (ATCC 55061) produced new antiviral antibiotics, cycloviracins B₁ and B₂. They show weak activity against Gram-positive bacteria and potent antiviral activity against herpes simplex virus type 1. Unique acylsaccharide structures were established for cycloviracins B₁ and B₂ by degradation and spectroscopic analysis.

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