IN VITRO AND IN VIVO ANTIFUNGAL ACTIVITIES OF BMS-181184

TOSHIKAZU OKI; MASATOSHI KAKUSHIMA; MINORU HIRANO; AKIYO TAKAHASHI; AKEMI OHTA; SHINJI MASUYOSHI; MASAMI HATORI; HIDEO KAMEI

doi:10.7164/antibiotics.45.1512

IN VITRO AND IN VIVO ANTIFUNGAL ACTIVITIES OF BMS-181184

TOSHIKAZU OKI, MASATOSHI KAKUSHIMA, MINORU HIRANO, AKIYO TAKAHASHI, AKEMI OHTA, SHINJI MASUYOSHI, MASAMI HATORI, HIDEO KAMEI

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JOURNAL FREE ACCESS

1992 Volume 45 Issue 9 Pages 1512-1517

DOI https://doi.org/10.7164/antibiotics.45.1512

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Abstract

BMS-181184 is a water-soluble pradimicin derivative with a broad antifungal spectrum in vitro and demonstrable efficacy against systemic infections with Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus in normal and cyclophosphamide-treated immunosuppressed mice.

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