The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
ANTHRACYCLINE METABOLITES FROM BAUMYCIN-PRODUCING Streptomyces sp. D788
II. NEW ANTHRACYCLINE METABOLITES PRODUCED BY A BLOCKED MUTANT STRAIN RPM-5
AKIHIRO YOSHIMOTOSHIZUKA FUJIIOSAMU JOHDOKATSURO KUBOHIROSHI NISHIDAROKURO OKAMOTOTOMIO TAKEUCHI
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1993 Volume 46 Issue 1 Pages 56-64

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Abstract

A daunorubicin-blocked mutant strain RPM-5 derived from a new baumycin-producing Streptomyces sp. D788 accumulated a major precursor metabolite D788-1 (10-carboxy-13-deoxocarminomycin) and nine minor metabolites in the culture broth. Five among them were new with a substituent at C-10 or the altered side chains at C-9. Isolation, purification and identification of all anthracycline metabolites produced by strain RPM-5 are described with their antitumor activities against L1210 cells.

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