FR901459, A NOVEL IMMUNOSUPPRESSANT ISOLATED FROM Stachybotrys chartarum No. 19392 TAXONOMY OF THE PRODUCING ORGANISM, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES

KAZUTOSHI SAKAMOTO; EISAKU TSUJII; MICHIYO MIYAUCHI; TOMOKO NAKANISHI; MICHIO YAMASHITA; NOBUHARU SHIGEMATSU; TOSHIHARU TADA; SHIZUE IZUMI; MASAKUNI OKUHARA

doi:10.7164/antibiotics.46.1788

FR901459, A NOVEL IMMUNOSUPPRESSANT ISOLATED FROM Stachybotrys chartarum No. 19392

TAXONOMY OF THE PRODUCING ORGANISM, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES

KAZUTOSHI SAKAMOTO, EISAKU TSUJII, MICHIYO MIYAUCHI, TOMOKO NAKANISHI, MICHIO YAMASHITA, NOBUHARU SHIGEMATSU, TOSHIHARU TADA, SHIZUE IZUMI, MASAKUNI OKUHARA

Author information

KAZUTOSHI SAKAMOTO
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
EISAKU TSUJII
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MICHIYO MIYAUCHI
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
TOMOKO NAKANISHI
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MICHIO YAMASHITA
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
NOBUHARU SHIGEMATSU
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
TOSHIHARU TADA
Analytical Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
SHIZUE IZUMI
Pharmacological Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MASAKUNI OKUHARA
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

JOURNAL FREE ACCESS

1993 Volume 46 Issue 12 Pages 1788-1798

DOI https://doi.org/10.7164/antibiotics.46.1788

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Abstract

FR901459, a novel immunosuppressant, has been isolated from the fermentation broth of Stachybotrys chartarum No. 19392. The molecular formula of FR901459 was determined as C₆₂H₁₁₁N₁₁O₁₃. FR901459 was found to be a member of the cyclosporin family. However, it is structurally distinct from any other cyclosporins discovered so far, in that Leu is present at position 5 instead of Val. FR901459 was capable of prolonging the survival time of skin allografts in rats with one third the potency of cyclosporin A.

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