THIOMARINOL, A NEW HYBRID ANTIMICROBIAL ANTIBIOTIC PRODUCED BY A MARINE BACTERIUM

FERMENTATION, ISOLATION, STRUCTURE, AND ANTIMICROBIAL ACTIVITY

Abstract

Thiomarinol, an antimicrobial antibiotic, was isolated from the culture broth of a marine bacterium, Alteromonas rava sp. nov. SANK 73390. Its structure was deduced as a hybrid composed of a pseudomonic acid analogue and holothin by NMR spectral analysis and chemical degradation. Antimicrobial activity against Gram-positive and Gram-negative bacteria of thiomarinol was stronger than both of pseudomonic acids and pyrrothine antibiotics.