UCT4B, A NEW ANTITUMOR ANTIBIOTIC WITH TOPOISOMERASE II MEDIATED DNA CLEAVAGE ACTIVITY STRUCTURE DETERMINATION

YOUICHI UOSAKI; SHO-ZOU KAWADA; HIROFUMI NAKANO; YUTAKA SAITOH; HIROSHI SANO

doi:10.7164/antibiotics.46.235

UCT4B, A NEW ANTITUMOR ANTIBIOTIC WITH TOPOISOMERASE II MEDIATED DNA CLEAVAGE ACTIVITY

STRUCTURE DETERMINATION

YOUICHI UOSAKI, SHO-ZOU KAWADA, HIROFUMI NAKANO, YUTAKA SAITOH, HIROSHI SANO

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JOURNAL FREE ACCESS

1993 Volume 46 Issue 2 Pages 235-240

DOI https://doi.org/10.7164/antibiotics.46.235

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Abstract

The relative stereo structure of UCT4B was determined by means of chemical derivatization and spectral analysis, in relation to known antitumor antibiotics terpentecin, which was simultaneously produced with UCT4B by Streptomyces sp.

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