A NEW NEURITOGENETIC COMPOUND BU-4514N PRODUCED BY Microtetraspora sp.

SOICHIRO TODA; SATOSHI YAMAMOTO; OSAMU TENMYO; TAKASHI TSUNO; TOSHIFUMI HASEGAWA; MARY ROSSER; MASAHISA OKA; YOSUKE SAWADA; MASATAKA KONISHI; TOSHIKAZU OKI

doi:10.7164/antibiotics.46.875

A NEW NEURITOGENETIC COMPOUND BU-4514N PRODUCED BY Microtetraspora sp.

SOICHIRO TODA, SATOSHI YAMAMOTO, OSAMU TENMYO, TAKASHI TSUNO, TOSHIFUMI HASEGAWA, MARY ROSSER, MASAHISA OKA, YOSUKE SAWADA, MASATAKA KONISHI, TOSHIKAZU OKI

Author information

SOICHIRO TODA
Bristol-Myers Squibb Research Institute
SATOSHI YAMAMOTO
Bristol-Myers Squibb Research Institute
OSAMU TENMYO
Bristol-Myers Squibb Research Institute
TAKASHI TSUNO
Bristol-Myers Squibb Research Institute
TOSHIFUMI HASEGAWA
Bristol-Myers Squibb Research Institute
MARY ROSSER
Bristol-Myers Squibb Research Institute
MASAHISA OKA
Bristol-Myers Squibb Research Institute
YOSUKE SAWADA
Bristol-Myers Squibb Research Institute
MASATAKA KONISHI
Bristol-Myers Squibb Research Institute
TOSHIKAZU OKI
Bristol-Myers Squibb Research Institute

JOURNAL FREE ACCESS

1993 Volume 46 Issue 6 Pages 875-883

DOI https://doi.org/10.7164/antibiotics.46.875

Details

Abstract

A novel neuritogenetic compound BU-4514N was isolated from the fermentation broth of Microtetraspora sp. T689-92. It showed significant NGF-mimic activity and antibacterial activity against Gram-positive bacteria. Structural studies revealed that BU-4514N was a new chemotype antibiotic related to lydicamycin.

Corresponding author

Register with J-STAGE for free!