RUMBRIN, A NEW CYTOPROTECTIVE SUBSTANCE PRODUCED BY Auxarthron umbrinum I. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL ACTIVITIES

YUJI YAMAGISHI; MICHIKO MATSUOKA; ATSUO ODAGAWA; SHINICHIRO KATO; KAZUTOSHI SHINDO; JUNICHIRO MOCHIZUKI

doi:10.7164/antibiotics.46.884

RUMBRIN, A NEW CYTOPROTECTIVE SUBSTANCE PRODUCED BY Auxarthron umbrinum

I. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL ACTIVITIES

YUJI YAMAGISHI, MICHIKO MATSUOKA, ATSUO ODAGAWA, SHINICHIRO KATO, KAZUTOSHI SHINDO, JUNICHIRO MOCHIZUKI

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JOURNAL FREE ACCESS

1993 Volume 46 Issue 6 Pages 884-887

DOI https://doi.org/10.7164/antibiotics.46.884

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Abstract

Rumbrin has been isolated from a fungus, Auxarthron umbrinum, by a screening program designed to find microorganism-produced cytoprotective substances. It was purified by use of column chromatography on silica gel, reversed phase HPLC and then isolated as fine red needles. Rumbrin prevented cell death caused by calcium overload and exhibited a potent inhibitory activity against lipid per oxidation.

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