LAGUNAMYCIN, A NOVEL 5-LIPOXYGENASE INHIBITOR I. TAXONOMY, FERMENTATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL CHARACTERISTICS

YOSHIMI NIHEI; MASAMI HASEGAWA; KIYOSHI SUZUKI; SATOSHI YAMAMOTO; MINORU HANADA; TAMOTSU FURUMAI; YASUO FUKAGAWA; TOSHIKAZU OKI

doi:10.7164/antibiotics.46.900

LAGUNAMYCIN, A NOVEL 5-LIPOXYGENASE INHIBITOR

I. TAXONOMY, FERMENTATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL CHARACTERISTICS

YOSHIMI NIHEI, MASAMI HASEGAWA, KIYOSHI SUZUKI, SATOSHI YAMAMOTO, MINORU HANADA, TAMOTSU FURUMAI, YASUO FUKAGAWA, TOSHIKAZU OKI

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JOURNAL FREE ACCESS

1993 Volume 46 Issue 6 Pages 900-907

DOI https://doi.org/10.7164/antibiotics.46.900

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Abstract

Lagunamycin, a novel 5-lipoxygenase inhibitor, was isolated from the culture broth of Streptomyces sp. AA0310. This compound showed potent rat 5-lipoxygenase inhibitory activity (IC₅₀ 6.08μM) without lipid peroxidation.

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