R1128 SUBSTANCES, NOVEL NON-STEROIDAL ESTROGEN-RECEPTOR ANTAGONISTS PRODUCED BY A Streptomyces II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE DETERMINATION

YASUHIRO HORI; SHIGEHIRO TAKASE; NOBUHARU SHIGEMATSU; TOSHIO GOTO; MASAKUNI OKUHARA; MASANOBU KOHSAKA

doi:10.7164/antibiotics.46.1063

R1128 SUBSTANCES, NOVEL NON-STEROIDAL ESTROGEN-RECEPTOR ANTAGONISTS PRODUCED BY A Streptomyces

II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE DETERMINATION

YASUHIRO HORI, SHIGEHIRO TAKASE, NOBUHARU SHIGEMATSU, TOSHIO GOTO, MASAKUNI OKUHARA, MASANOBU KOHSAKA

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JOURNAL FREE ACCESS

1993 Volume 46 Issue 7 Pages 1063-1068

DOI https://doi.org/10.7164/antibiotics.46.1063

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Abstract

R1128 A, B, C and D, new non-steroidal estrogen-receptor antagonists, were isolated from the cultured broth of Streptomyces sp. No. 1128. Their structures were elucidated to be l, 3, 6-trihydroxy-8-alkylanthraquinones on the basis of their physico-chemical properties and spectroscopic data.

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