The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
TAUTOMERIC PHENOMENON OF A NOVEL POTENT IMMUNOSUPPRESSANT (FK506) IN SOLUTION
I. ISOLATION AND STRUCTURE DETERMINATION OF TAUTOMERIC COMPOUNDS
Y. NAMIKIN. KIHARAS. KODAK. HANET. YASUDA
Author information
JOURNALS FREE ACCESS

1993 Volume 46 Issue 7 Pages 1149-1155

Details
Abstract

Tautomeric phenomenon was observed in the HPLC chromatogram obtained from a novel potent immunosuppressant, FK506, in ethanol solution. Two tautomeric compounds derived from FK506 were isolated and purified by HPLC. Their structures were elucidated by spectral analyses. The mechanisms for this tautomerization were also established based on the results of structure analysis.

Information related to the author
© Japan Antibiotics Research Association
Previous article Next article
feedback
Top