AS-183, A NOVEL INHIBITOR OF ACYL-CoA: CHOLESTEROL ACYLTRANSFERASE PRODUCED BY Scedosporium sp. SPC-15549

KAZUTOSHI KURODA; MAYUMI YOSHIDA; YOUICHI UOSAKI; KATSUHIKO ANDO; ISAO KAWAMOTO; EIKO OISHI; HIROKI ONUMA; KOJI YAMADA; YUZURU MATSUDA

doi:10.7164/antibiotics.46.1196

AS-183, A NOVEL INHIBITOR OF ACYL-CoA: CHOLESTEROL ACYLTRANSFERASE PRODUCED BY Scedosporium sp. SPC-15549

KAZUTOSHI KURODA, MAYUMI YOSHIDA, YOUICHI UOSAKI, KATSUHIKO ANDO, ISAO KAWAMOTO, EIKO OISHI, HIROKI ONUMA, KOJI YAMADA, YUZURU MATSUDA

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JOURNAL FREE ACCESS

1993 Volume 46 Issue 8 Pages 1196-1202

DOI https://doi.org/10.7164/antibiotics.46.1196

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Abstract

A novel compound, AS-183, which inhibits acyl-CoA: cholesterol acyltransferase (ACAT), was isolated from the culture broth of a fungus, Scedosporium sp. SPC-15549. AS-183 inhibited ACAT activity in an enzyme assay system using rabbit liver microsomes with an IC₅₀ value of 0.94μM. AS-183 also inhibited cholesterol ester formation in HepG2, CaCo2, and THP-1 cells with IC₅₀ values of 18.1, 25.5, and 34.5μM, respectively.

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