TOTALLY SYNTHETIC ANALOGUES OF SIASTATIN B III. TRIFLUOROACETAMIDE ANALOGUES HAVING INHIBITORY ACTIVITY FOR TUMOR METASTASIS

Yoshio NISHIMURA; Toshiaki KUDO; Shinichi KONDO; Tomio TAKEUCHI; TSUTOMU TSURUOKA; HARUMI FUKUYASU; SEUI SHIBAHARA

doi:10.7164/antibiotics.47.101

TOTALLY SYNTHETIC ANALOGUES OF SIASTATIN B

III. TRIFLUOROACETAMIDE ANALOGUES HAVING INHIBITORY ACTIVITY FOR TUMOR METASTASIS

Yoshio NISHIMURA, Toshiaki KUDO, Shinichi KONDO, Tomio TAKEUCHI, TSUTOMU TSURUOKA, HARUMI FUKUYASU, SEUI SHIBAHARA

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JOURNAL FREE ACCESS

1994 Volume 47 Issue 1 Pages 101-107

DOI https://doi.org/10.7164/antibiotics.47.101

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Abstract

A trifluoroacetamide analogue of siastatin B, (3R, 4R, 5R, 6R)-6-(trifluoroacetamido)-4, 5-dihydroxy-3-piperidinecarboxylic acid has been chemically synthesized. This compound, as well as the previously synthesized analogue, (3R, 4R, 5R, 6R)-6-(triiluoroacetamido)-3, 4, 5-trihydroxy-3-piperidinecarbo xylic acid, showed marked inhibitory activity against δ-glucuronidase and significant inhibition of experimental pulmonary metastasis of the highly metastatic melanoma B16.

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