The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
WF11899A, B AND C, NOVEL ANTIFUNGAL LIPOPEPTIDES
II. BIOLOGICAL PROPERTIES
TOSHIRO IWAMOTOAKIHIKO FUJIEKUMIKO NITTASEIJI HASHIMOTOMASAKUNI OKUHARAMASANOBU KOHSAKA
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1994 Volume 47 Issue 10 Pages 1092-1097

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Abstract

WF11899A, B and C, novel water-soluble lipopeptides related to the echinocandins, possess potent anti-Candida activities. The IC50s of the compounds against four clinical isolates of Candida albicans ranged from 0.004 to 0.03 μg/ml by microbroth dilution assay. These compounds mildly suppressed the growth of Aspergillus fumigatus and A. niger. WF11899A, B and C showed a potent in vivo anti-Candida activity. Particularly, WF11899A was superior to cilofungin, and equal to fluconazole. 1, 3-β-glucan synthase was inhibited by these compounds at the IC50s of 0.7, 0.7 and 1.8μg/ml for WF 11899A, B and C, respectively. However, they hemolysed mouse red blood cells in vitro at the concentration of 62 μg/ml.

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