ALDECALMYCIN, A NEW ANTIMICROBIAL ANTIBIOTIC FROM Streptomyces I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

RYUICHI SAWA; YOSHIKAZU TAKAHASHI; SAKIKO ITOH; KAZUO SHIMANAKA; NAOKO KINOSHITA; YOSHIKO HOMMA; MASA HAMADA; TSUTOMU SAWA; HIROSHI NAGANAWA; TOMIO TAKEUCHI

doi:10.7164/antibiotics.47.1266

ALDECALMYCIN, A NEW ANTIMICROBIAL ANTIBIOTIC FROM Streptomyces

I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

RYUICHI SAWA, YOSHIKAZU TAKAHASHI, SAKIKO ITOH, KAZUO SHIMANAKA, NAOKO KINOSHITA, YOSHIKO HOMMA, MASA HAMADA, TSUTOMU SAWA, HIROSHI NAGANAWA, TOMIO TAKEUCHI

Author information

RYUICHI SAWA
Institute of Microbial Chemistry
YOSHIKAZU TAKAHASHI
Institute of Microbial Chemistry
SAKIKO ITOH
Institute of Microbial Chemistry
KAZUO SHIMANAKA
Institute of Microbial Chemistry
NAOKO KINOSHITA
Institute of Microbial Chemistry
YOSHIKO HOMMA
Institute of Microbial Chemistry
MASA HAMADA
Institute of Microbial Chemistry
TSUTOMU SAWA
Institute of Microbial Chemistry
HIROSHI NAGANAWA
Institute of Microbial Chemistry
TOMIO TAKEUCHI
Institute of Microbial Chemistry

JOURNAL FREE ACCESS

1994 Volume 47 Issue 11 Pages 1266-1272

DOI https://doi.org/10.7164/antibiotics.47.1266

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Abstract

A new antibiotic, aldecalmycin, has been discovered in the culture broth of Streptomyces sp. MJ147-72F6. Aldecalmycin was purified by solvent extraction, Diaion HP-20 chromatography, silica gel chromatography, Sephadex LH-20 chromatography, HPLC and centrifugal partition chromatography. The ¹H and ¹³C NMR spectra of aldecalmycin showed the presence of keto-enol tautomers. Aldecalmycin is equipotent in inhibiting the growth of sensitive and methicillin-resistant Staphylococcus aureus (MRSA).

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