The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ALDECALMYCIN, A NEW ANTIMICROBIAL ANTIBIOTIC FROM Streptomyces
I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES
RYUICHI SAWAYOSHIKAZU TAKAHASHISAKIKO ITOHKAZUO SHIMANAKANAOKO KINOSHITAYOSHIKO HOMMAMASA HAMADATSUTOMU SAWAHIROSHI NAGANAWATOMIO TAKEUCHI
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1994 Volume 47 Issue 11 Pages 1266-1272

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Abstract

A new antibiotic, aldecalmycin, has been discovered in the culture broth of Streptomyces sp. MJ147-72F6. Aldecalmycin was purified by solvent extraction, Diaion HP-20 chromatography, silica gel chromatography, Sephadex LH-20 chromatography, HPLC and centrifugal partition chromatography. The 1H and 13C NMR spectra of aldecalmycin showed the presence of keto-enol tautomers. Aldecalmycin is equipotent in inhibiting the growth of sensitive and methicillin-resistant Staphylococcus aureus (MRSA).

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