The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
ISOLATION AND CHARACTERIZATION OF A NEW 12-MEMBERED MACROLIDE FD-895
MITSUKO SEKI-ASANOTADAYASU OKAZAKIMICHIO YAMAGISHINORIYOSHI SAKAIYASUKO TAKAYAMAKAZUNORI HANADASIGEO MORIMOROAKIRA TakatsukiKAZUNORI Mizoue
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1994 Volume 47 Issue 12 Pages 1395-1401

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Abstract

During the course of our screening program for natural product drugs effective against multidrug resistant cells by using adriamycin resistant HL-60 cells, we have discovered a new 12 membered macrolide FD-895 in the fermentation broth of Streptomyces hygroscopicus A-9561 isolated from a soil sample collected at Iriomote Island, Okinawa prefecture, Japan. FD-895 showed stronger cytocidal activities against in vitro tumor cell lines than adriamycin. FD-895 had the same IC50 values against parent and adriamycin resistant HL-60 cells.

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© Japan Antibiotics Research Association
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