MATLYSTATINS, NEW INHIBITORS OF TYPE IV COLLAGENASES FROM Actinomadura atramentaria

III. STRUCTURE ELUCIDATION OF MATLYSTATINS A TO F

Abstract

The structures of matlystatins, novel type IV collagenase inhibitors isolated from Actinomadura atramentaria, have been determined by a systematic application of homo- and heteronuclear 2D NMR and FAB-MS/MS techniques. Their structures were characterized by the presence of piperazic acid and hydroxamic acid moieties, structural motifs often seen in protease inhibitors.