BE-23372M, A NOVEL PROTEIN TYROSINE KINASE INHIBITOR

II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION

Abstract

BE-23372M, a new protein tyrosine kinase inhibitor, has been obtained as a reddish orange solid. The compound, C₁₇H₁₂O₆, HRFAB-MS: m/z 312.0625 (M)⁺, is an acidic substance, showing UV (MeOH)λ_max (ε) 266 (8, 800), 426 nm (20, 400), and IR (KBr)ν_max 1752(C=O) and 3298(OH) cm^-1. The structure of BE-23372M, (E)-3-(3, 4-dihydroxybenzylidene)-5-(3, 4-dihydroxyphenyl)-2(3H)-furanone, has been elucidated by ¹H and ¹³C NMR studies.