The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Tetrodecamycin and Dihydrotetrodecamycin, New Antimicrobial Antibiotics against Pastemella piscicida Produced by Streptomyces nashvillensis MJ885-mF8
I. Taxonomy, Fermentation, Isolation, Characterization and Biological Activities
TOSHIO TSUCHIDAHIRONOBU IINUMACHIGUSA NISHIDANAOKO KINOSHITATSUTOMU SAWAMASA HAMADATOMIO TAKEUCHI
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1995 Volume 48 Issue 10 Pages 1104-1109

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Abstract

The novel antimicrobial antibiotic against Pasteurella piscicida, tetrodecamycin (1) and weakly active dihydrotetrodecamycin (2) were isolated from the fermentation broth of Streptomyces nashvillensis MJ885-mF8. They were purified by adsorption on Diaion HP-20, silica gel column chromatography and crystallization. The MICs of 1 were 6.25-12.5μg/liter and 1.56-6.25μg/ml against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and 12 strains of P. piscicida, respectively.

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© Japan Antibiotics Research Association
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