Stachybocins, Novel Endothelin Receptor Antagonists, Produced by Stachybotrys sp. M6222 II. Structure Determination of Stachybocins A, B and C

KIYOSHI OGAWA; MASATO NAKAMURA; MITSUO HAYASHI; SATOSHI YAGINUMA; SYUJI YAMAMOTO; KAZUO FURIHATA; KAZUO SHIN-YA; HARUO SETO

doi:10.7164/antibiotics.48.1396

Stachybocins, Novel Endothelin Receptor Antagonists, Produced by Stachybotrys sp. M6222

II. Structure Determination of Stachybocins A, B and C

KIYOSHI OGAWA, MASATO NAKAMURA, MITSUO HAYASHI, SATOSHI YAGINUMA, SYUJI YAMAMOTO, KAZUO FURIHATA, KAZUO SHIN-YA, HARUO SETO

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JOURNAL FREE ACCESS

1995 Volume 48 Issue 12 Pages 1396-1400

DOI https://doi.org/10.7164/antibiotics.48.1396

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Abstract

The structures of Stachybocins A, B and C, new endothelin receptor antagonists, were determined by NMR spectral analysis using pulse-field-gradient techniques. Stachybocin A consists of two spirobenzofuran units each fused to a substituted decalin, which were connected by a lysine residue. Stachybocins B and C are derivatives of Stachybocin A with an additional hydroxy group at the same position in the different decalin unit.

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