Paeciloquinones A, B, C, D, E and F: New Potent Inhibitors of Protein Tyrosine Kinase Produced by Paecilomyces carneus

II. Characterization and Structure Determination

Abstract

Paeciloquinones A to F and versiconol have been isolated as inhibitors of protein tyrosine kinases from the culture broth of the fungus Paecilomyces carneus P-177. The structures of the new anthraquinones were determined by spectroscopic methods, mainly ¹H NMR and ¹³C NMR. The substitution pattern was established by investigation of the respective methylated derivatives.