New Glycosidases Inhibitors, Panosialins D and wD Produced by Streptomyces sp. OH-5186

Abstract

New panosialin analog, panosialins D and wD have been isolated from the culture broth of Streptomyces sp. OH-5186. Their structures were elucidated as 5-(13-methylpentadecyl)-1, 3-benzenediol bis(sodium sulfate) and 5-(13-methylpentadecyl)-1, 3-benzenediol 1-(sodium sulfate), respectively. They showed strong inhibitory activity against α-mannosidase, α-glucosidase, and β-glucosidase. Panosialins wA-wD mixture also showed weak mitogenic activity but suppressed the mitogen induced activity.