The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Action of Cytogenin on Lymphoid Cells and Their Cytokine Production
HIROYUKI KUMAGAIMICHIYO OSONOMASATOMI IIJIMAMIYUKI SAKASHITAMASAAKI ISHIZUKATOMIO TAKEUCHI
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1995 Volume 48 Issue 4 Pages 317-320

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Abstract

Action of cytogenin on macrophages and T cells was investigated. Phagocytosis of yeast and production of PMA-elicited superoxide anion by macrophages taken from mice given cytogenin po were augmented. Cytogenin enhanced productions of IL-1α by macrophages and IFNγ and GM-CSF by spleen cells although it did not enhanced production of TNFα by macrophages and IL-6 by macrophages and spleen cells. Macrophages stimulated with cytogenin caused to stimulate proliferation of purified T cells in Intercell cultures in which each cell population was cultured without contact. Results suggest that cytogenin primarily activates macrophages to produce monokines such as IL-1α and it causes to stimulate proliferation and differentiation of T cells resulting in production of lymphokines such as IFNγ and GM-CSF.

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