The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Production of the New Antibiotic Tetrahydrokalafungin by Transformants of the Kalafungin Producer Streptomyces tanashiensis
SHIZUKO KAKINUMAHARUO IKEDAYOSHIO TAKADAHARUO TANAKADAVID A. HOPWOODSATOSHI OMURA
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1995 Volume 48 Issue 6 Pages 484-487

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Abstract

The new antibiotic tetrahydrokalafungin was produced by the transformants of kalafungin producing S. tanashiensis and kalafungin-nonproducing mutants carrying the recombinant plasmid pKU523. This plasmid consists of pKU501 (J. Antibiotics 44: 995-1005, 1991) which contains the gene cluster for kalafungin biosynthesis, and additional 5kb stability region of SCP2*.

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© Japan Antibiotics Research Association
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