The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Concanamycin B Inhibits the Expression of Newly-synthesized MHC Class II Molecules on the Cell Surface
KOUICHI ITOTSUYOSHI KOBAYASHIYOSHINORI MORIYAMAKAZUNOBU TOSHIMAKUNIAKI TATSUTATERUTAKA KAKIUCHIMASAMITSU FUTAIHIDDE L. PLOEGHKIYOSHI MIWA
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1995 年 48 巻 6 号 p. 488-494

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We screened natural chemical compounds which inhibit the expression of newly-synthesized MHC class II molecules on the cell surface. IFN-γ stimulates Colo 205 adenocarcinoma cells to induce the expression of MHC class I, MHC class II, and 1C AM-1 molecules on the cell surface. We show here that concanamycin B inhibits the expression of MHC class II molecules on Colo 205 cells, whereas it does not affect the expression of MHC class I and ICAM-1 molecules. Concanamycin B also abrogates the enhancement of the MHC class II expression by IL-4 on mouse lymphocytes. Furthermore, concanamycin B suppresses the antigen presentation by MHC class II molecules.

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© Japan Antibiotics Research Association
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