Pyripyropenes, Novel AC AT Inhibitors Produced by Aspergillus fumigatus III. Structure Elucidation of Pyripyropenes E to L

HIROSHI TOMODA; NORIKO TABATA; DA-JUN YANG; HIROAKI TAKAYANAGI; HIROYUKI NISHIDA; SATOSHI OMURA; TAKUSHI KANEKO

doi:10.7164/antibiotics.48.495

Pyripyropenes, Novel AC AT Inhibitors Produced by Aspergillus fumigatus

III. Structure Elucidation of Pyripyropenes E to L

HIROSHI TOMODA, NORIKO TABATA, DA-JUN YANG, HIROAKI TAKAYANAGI, HIROYUKI NISHIDA, SATOSHI OMURA, TAKUSHI KANEKO

Author information

HIROSHI TOMODA
Research Center for Biological Function, The Kitasato Institute, and School of Pharmaceutical Sciences, Kitasato University
NORIKO TABATA
Research Center for Biological Function, The Kitasato Institute, and School of Pharmaceutical Sciences, Kitasato University
DA-JUN YANG
Research Center for Biological Function, The Kitasato Institute, and School of Pharmaceutical Sciences, Kitasato University
HIROAKI TAKAYANAGI
Research Center for Biological Function, The Kitasato Institute, and School of Pharmaceutical Sciences, Kitasato University
HIROYUKI NISHIDA
Research Center for Biological Function, The Kitasato Institute, and School of Pharmaceutical Sciences, Kitasato University
Present address: Pfizer Central Research, Nagoya, Pfizer Pharmaceuticals Inc.
SATOSHI OMURA
Research Center for Biological Function, The Kitasato Institute, and School of Pharmaceutical Sciences, Kitasato University
TAKUSHI KANEKO
Central Research Division, Pfizer Inc.

JOURNAL FREE ACCESS

1995 Volume 48 Issue 6 Pages 495-503

DOI https://doi.org/10.7164/antibiotics.48.495

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Abstract

Eight new pyripyropenes, E to L, were isolated from the culture broth of Aspergillus fumigatus FO-1289-2501 selected as a higher producer by NTG mutation. Structural elucidation indicated that all the pyripyropenes have the same pyridino-α-pyrone sesquiterpene core as pyripyropenes A to D. Among them, pyripyropene L showed the most potent inhibition against acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ value of 0.27 μM in rat liver microsomes.

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