Chemical Modification of Tylosin

SYLVIE BOBILLOT; TAMAS BAKOS; PIERRE SARDA; TON THAT THANG; LI MING; ALAIN OLESKER; GABOR LUKACS

doi:10.7164/antibiotics.48.667

SYLVIE BOBILLOT, TAMAS BAKOS, PIERRE SARDA, TON THAT THANG, LI MING, ALAIN OLESKER, GABOR LUKACS

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JOURNAL FREE ACCESS

1995 Volume 48 Issue 7 Pages 667-670

DOI https://doi.org/10.7164/antibiotics.48.667

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Abstract

20-Homo tylosin, 20-nor tylosin, 20-deoxy-19, 20-didehydro tylosin (6-vinyl tylosin) and 2", 3"-didehydro-3"-deoxy tylosin were prepared by multi-step procedures. 20-Homo tylosin was about twice less active than tylosin while the other coumpounds exhibited very weak antibacterial activity.

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