The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
New Antitumor Substances, FR901463, FR901464 and FR901465
I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
HIDENORI NAKAJIMABUNJI SATOTAKASHI FUJITASHIGEHIRO TAKASEHIROSHI TERANOMASAKUNI OKUHARA
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1996 Volume 49 Issue 12 Pages 1196-1203

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Abstract

New antitumor substances, FR901463, FR901464 and FR901465 were isolated from the culture broth of a bacterium of Pseudomonas sp. No.2663.
FR901463, FR901464 and FR901465 remarkably enhanced the transcriptional activity of the promoter of SV40 DNA virus. Further, these compounds exhibited potent anti tumor activities against murine and human tumor cell lines in vitro.

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