The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Dibefurin, a Novel Fungal Metabolite Inhibiting Calcineurin Phosphatase Activity
GREGORY M. BRILLUSHA PREMACHANDRANJAMES P. KARWOWSKIRODGER HENRYDOLORES K. CWIKLINDA M. TRAPHAGENPATRICK E. HUMPHREYMARIANNA JACKSONJACOB J. CLEMENTNEAL S. BURRESSUNIL KADAMRANDAL H. CHENJAMES B. MCALPINE
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1996 Volume 49 Issue 2 Pages 124-128

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Abstract

The novel calcineurin inhibitor, dibefurin, has been isolated from the fungal culture AB 16501-759. The isolation was bioactivity-directed fractionation using an assay which measures the phosphatase activity of calcineurin. The compound was purified by countercurrent, reverse phase and gel filtration chromatographics. Several studies, including crystallographic, NMR and MS, revealed that dibefurin is a novel dimeric compound of a unique structural type.

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