Studies on Cochleamycins, Novel Antitumor Antibiotics

III. Biosyntheses of Cochleamycins: Incorporation of ¹³C-and ²H-Labeled Compounds into Cochleamycins

Abstract

Biosynthetic studies using ¹³C- and ²H-labeled compounds revealed that the carbon skeletons of Cochleamycins A and B were derived from eight acetic acid units and one propionic acid unit with the introduction of an acetoxy group at C-10, which was replaced by an isobutyryl residue derived from valine in Cochleamycins A2 and B2.