The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
YM-47522, a Novel Antifungal Antibiotic Produced by Bacillus sp.
I. Taxonomy, Fermentation, Isolation and Biological Properties
MITSUYOSHI SHIBAZAKITAKEO SUGAWARAKOJI NAGAIYASUYO SHIMIZUHIROSHI YAMAGUCHIKENICHI SUZUKI
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1996 Volume 49 Issue 4 Pages 340-344

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Abstract

YM-47522, a novel antibiotic, was isolated from the culture broth of Bacillus sp. YL-03709B. The antibiotic was purified by centrifugal partition chromatography and ODS column chromatography. It exhibited potent in vitro antifungal activity especially against Rhodotorula acuta and Pichia angusta (MIC: 0.05 and 0.75 μg/ml, respectively). It also showed moderate or weak antifungal activity against Candida albicans and Cryptococcus neoformans (MIC: 25 and 6.25 μg/ml, respectively), whereas it was inactive against filamentous fungi and bacteria.

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