The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
CJ-12, 954 and Its Congeners, New Anti-Helicobacter pylori Compounds Produced by Phanerochaete velutina:
Fermentation, Isolation, Structural Elucidation and Biological Activities
KOEN A. DEKKERTAISUKE INAGAKITHOMAS D. GOOTZKEIJI KANEDAETSUKO NOMURATATSUO SAKAKIBARASHINICHI SAKEMIYUTAKA SUGIEYUJI YAMAUCHINOBUJI YOSHIKAWANAKAO KOJIMA
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1997 Volume 50 Issue 10 Pages 833-839

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Abstract

Seven new phthalide compounds with anti-Helicobacter pylori activities were isolated from the basidiomycete Phanerochaete velutina CL6387, The two most potent phthalide compounds, CJ-12, 954 and CJ-13, 014, have MICs of 5ng/ml. The structure-activity relationship shows that the presence of a spiroketal part in addition to the phthalide part, greatly enhances the activity. The phthalide compounds appear to be specific for H. pylori, since they did not show antibacterial activities when tested against a panel of other microorganisms.

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