The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Epoxyquinoniicins A, B, C and D, New Antibiotics from Amycolatopsis
II. Effect on Type II Collagen-induced Arthritis in Mice
NAOKI MATSUMOTOHIRONOBU IINUMATSUTOMU SAWATOMIO TAKEUCHISHIN-ICHI HIRANOTAKEO YOSHIOKAMASAAKI ISHIZUKA
Author information
JOURNALS FREE ACCESS

1997 Volume 50 Issue 11 Pages 906-911

Details
Abstract

The anti-arthritic effects of epoxyquinomicins on type II collagen-induced arthritis in DBA/1J mice were examined. Prophylactic treatment with epoxyquinomicins A, B, C and D (1-4mg/kg) had potent inhibitory effects on type II collagen-induced arthritis. In contrast to nonsteroidal antiinflammatory drugs (NSAIDs), epoxyquinomicin C (1-30mg/kg) had neither an anti-inflammatory effect on carrageenan-induced paw edema in rats nor an analgesic effect on acetic acid-induced writhing in mice. These results suggest that the mode of action of epoxyquinomicins is different from that of NSAIDs and that epoxyquinomicins may become useful drugs for the treatment of rheumatoid arthritis.

Information related to the author
© Japan Antibiotics Research Association
Previous article Next article
feedback
Top